Prenatal serum screening

Solutions for every stage of pregnancy

More choice. Better care. 

Whether your laboratory specializes in automated high throughput or clinic-level prenatal screening, we meet the needs of your screening program from sample to report.

Our prenatal serum screening solutions cover not only every stage of pregnancy, but also the entire range of modern screening strategies and the latest advances in prenatal care.

Full support for earlier detection

In the first trimester, our assays – PAPP-A, free hCGß, PlGF and AFP – provide effective screening for aneuploidy and other complications of pregnancy. The markers can be used as part of the combined (PAPP-A, free hCGß) or expanded combined (PAPP-A, free hCGß, PlGF and AFP) model when ultrasound is available or the 1T QUAD biochemistry-only model. Our dried blood spot (DBS) assay is also optimized for first trimester. 

In the second trimester, our assay solutions support all second trimester screening models: 2T Double, 2T Triple and the 2T Quad test. 

Screening solutions for each trimester
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PAPP-A/Free hCGß Dual DBS
Free hCGß
hAFP/Free hCGß Dual
hAFP/Free hCGß Dual
* PlGF for pre-eclampsia screening
** Inhibin-A only available on AutoDELFIA®

1T QUAD – biochemistry only screening for first trimester

PerkinElmer is the only company to offer four CE-marked assays – PAPP-A, free hCGß, PlGF and AFP – for first trimester screening of Down syndrome.

When combined, these assays provide reliable screening for common aneuploidies in the first trimester even in the absence of nuchal translucency (NT) measurement (Huang et al. 2015).

With the 1T QUAD, you can achieve similar screening performance already in the first trimester as with the 2T Quad in the second trimester (Johnson et al. 2013).

Why choose 1T QUAD?

  • New biochemistry-only screening protocol for Down syndrome in the first trimester
  • When NT measurement is not available - achieve performance equivalent to 2T screening
  • Earlier risk assessment of other pregnancy complications like pre-eclampsia 
  • Cost-efficient management of screening resources 

DBS - reach more women with your screening program

Our DELFIA®/AutoDELFIA® PAPP-A/Free hCGß Dual DBS (dried blood spot) assay supports easier access to prenatal screening in regions where storage and shipment of serum samples can be a challenge. The sampling process is simple and the blood spot is obtained by finger-prick.


PerkinElmer first trimester assays for Free hCGβ, PAPP-A, AFP and PlGF on the AutoDELFIA and DELFIA Xpress platforms and DELFIA/Auto DELFIA PAPP-A/Free hCGβ Dual DBS assay are approved by the Fetal Medicine Foundation (FMF).

Contingent screening – focus your resources more effectively

No further testing for aneuploidy
Refer to further testing
Early prenatal diagnosis

Contingent screening is used to divide pregnant women into three risk categories based on first trimester screening. Women in the high-risk category are immediately offered a diagnostic test, while women at low risk of pregnancy complications require no further testing. Women with a risk between the two cut-offs undergo integrated testing in the second trimester.

Contingent screening is also a cost-effective way to select women in the medium risk category for cfDNA testing if the use of NIPT is limited by cost or availability. If ultrasound testing is not readily available, 1T QUAD can be used as the first-tier screening solution for aneuploidy and pre-eclampsia, with women in the medium risk category being referred to NT measurement.

Our screening solutions support contingent screening strategies – helping you get more out of your screening program at less cost.

Products may not be licensed in accordance with their laws in all countries, such as the United States and Canada. Please check with your local representative for availability.
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